Shannon Cram explores the slippery subjectivities of nuclear waste and nature at Washington State’s Hanford Nuclear Reservation, examining how this space is framed as both pristine habitat and waste frontier. She examines Hanford’s biological vector control program through the fruit fly and discusses how vector control uses instances of nuclear trespass to articulate the boundary between contaminated and uncontaminated. She concludes that nature is being recruited to do what the U.S. Department of Energy cannot: solve Hanford’s nuclear waste problem.